Major war has returned to the Middle East. The US and Israel’s weekend assassination of the Islamist cleric who had ruled Iran since the 1980s was of global consequence, coming just weeks after the US plucked Venezuela’s leader from Caracas and jailed him in New York. Nobody knows how the conflict engulfing the entire Middle-East region will play out, but a Pandora’s box has been opened. As I wrote 14 months ago, if a regime in Iran were to emerge that is more similar to those in the other big powers in the Middle East, it would be good for…